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In a 2011 study, Benoist and colleagues established that the procognitive core of Nle 1 -Ang IV resides in its three N-terminal residues (Nle-Tyr-Ile), and that C-terminally truncated tetrapeptides and tripeptides retained scopolamine-reversal activity in the Morris water maze [1]

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In PD patients, tau and A proteins can interact with -Syn to enhance each others aggregation and deposition, hastening the course of cognitive impairment ( Tau proteins attach to microtubule proteins to facilitate the production of microtubules, in turn forming the neuronal cytoskeleton

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[DOI] [PMC free article] [PubMed] [Google Scholar] 237.Meng X.M., Nikolic-Paterson D.J., Lan H.Y