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Well, this is pure speculation, but a high blood methionine concentration can lead to its oxidation and the alteration of the structural integrity of the cells

Huang H, Yin R, Zhu J, Feng X, Wang C, et al

While both diets were low in calories and fat, only the low-GI diet improved overall insulin sensitivity, fibrinogen levels (an inflammatory protein), and menstrual regularity, highlighting its superior metabolic benefits

FIGURE 3 3.3 Effects of sensors in different pH reactants To explore the best working pH of the electrochemical sensor to allow it to successfully recognize IL-6 antigen in the pH environment of the real sample, we studied its performance in different pH reaction systems

The development of selective delivery systems, including nanoparticle-based carriers or tumor-targeted prodrugs, alongside adaptive clinical trial designs incorporating metabolic biomarkers, will be pivotal in overcoming these hurdles