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Evidently, intracellular cyst(e)ine contribute to ferroptosis suppression via at least two additional pathways in different contexts: in a mouse lung adenocarcinoma model, NFS1 cysteine desulfurase utilizes cysteine to synthesize ironsulfur clusters, which are necessary for preventing activation of the iron-starvation response, subsequent iron influx and ferroptosis 14 (Fig

Arystan N

Such a mechanism could theoretical be mediated by the oncoprotein MDM2, which interacts with p53 but has recently also been found to associate with certain cell surface receptors and regulate their functions (Shenoy et al, 2001)

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