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However, so far, there have been few reports on the use of such drugs with BBB-crossing capability for the treatment of PD

F., Crespi, C

doi:10.1093/jn/130.4.1049S

Hydrogen nutrition therapy application in obesity and metabolic disorders The excessive production of free radicals can induce discontinuation of the gastrointestinal tract barrier, thereby causing the inflammation and the loss of redox homeostasis observed in some gastrointestinal diseases and implicated in the pathogenesis of several gastrointestinal disorders [2]

These actions are mediated through enhanced mitochondrial biogenesis and ATP production, inhibition of inflammatory signaling, and preservation of nigrostriatal dopaminergic neurons, collectively leading to improved motor and non-motor functional outcomes (Zhu et al., 2017