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The phenotype is defined by short stature and generalized muscular hypotonia as major criteria, and skin hyperextensibility, soft doughy skin, pes planus, delayed motor and cognitive development and osteopenia as minor criteria

"A diet that includes meat, fish and dairy products usually provides enough vitamin B12, but people who do not regularly eat these foods can become deficient," notes the NHS

Knowing your genetic profile before titration helps your PlexusDx provider select optimal doses and formulations to minimize chills and maximize tolerability

Monitoring frequency can decrease once levels stabilize, but periodic reassessment remains important for ongoing management

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