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[9] Humans express three thioredoxin reductase isozymes: thioredoxin reductase 1 (TrxR1, cytosolic), thioredoxin reductase 2 (TrxR2, mitochondrial), thioredoxin reductase 3 (TrxR3, testis specific)

This biosynthetic process is mediated by glutamate-cysteine ligase (GCL), which includes glutamate-cysteine ligase catalytic subunit(GCLC) and GSH synthetase(GSS) [8]

Glutaminase is produced by two different genes: GLS1 and GLS2

It was evidenced by the activation of Wnt and NF-B signaling transduction and the expression of differentiation markers [COL1A, alkaline phosphatase, osteocalcin (OCN), core-binding factor alpha 1, and osteoprotegerin

doi: 10.1186/2040-2392-4-42 260 ParrachoHMBinghamMOGibsonGRMcCartneyAL
