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They are generally not recommended during pregnancy or breastfeeding, for people with a known allergy to any component of the formulation, or for those with certain medical conditions

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Keywords: Endothelial dysfunction, Endothelium-dependent vasodilation, Endothelial nitric oxide synthase, Inflammation, Nitric oxide, Pharmacological treatment, Reactive nitrogen species, Reactive oxygen species, Risk factors Core tip: The endothelium is involved in the regulation of vascular tone and permeability, coagulation and fibrinolysis, inflammatory and immunological reactions and cell growth

Bohrerova et al