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Decreased expression of GPx1 by iberin results in an accumulation of detrimental concentrations of ROS (measured by DCF fluorescence) that inhibits cell proliferation, induces cell cycle arrest, and promotes apoptosis, whereas the forced upregulation of GPx1 or antioxidant treatment attenuates these therapeutic actions [143]

BNIP3-mediated mitophagy in macrophages regulates obesity-induced adipose tissue metaflammation

doi: 10.7150/thno.86831

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Optimize vitamin D status, as vitamin D upregulates endogenous cathelicidin/LL-37 expression [10]