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In our current study we demonstrated that in multiple in vivo and in vitro PD models, LRRK2 and PINK1 may form a functional protein kinase pair to modulate TH-DA pathway ( Figure 1 )

64 Notably, cationic delivery strategies require careful design to support weak, reversible interactions with the cartilage matrix, because an excessively positive charge may favor tight binding, potentially limiting penetrability

Nano Energy 109 , 108290 (2023)