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TNF-: tumor necrosis factor- (purple)

Neuroinflammation in ME/CFS was initially suggested by studies showing elevated levels of pro-inflammatory cytokines, and decreased anti-inflammatory cytokines, in cerebrospinal fluid from lumbar punctures in ME/CFS patients [62, 63], and further supported by a positron emission tomography (PET) study [64], which showed increased binding of a radioligand to 18 kDa translocator protein (TSPO) receptor, the expression of which increases when microglia are activated

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*Correspondence: Roberto Badaro, [email protected];[email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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