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When present in adequate concentrations, the compound enhances nitric oxide production through upregulation of endothelial nitric oxide synthase (eNOS) expression and activity, promoting vasodilation and improving blood flow

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Statistical significance was calculated as the significance of the difference between the upper limit of normal and the group mean for each acyl-carnitine specific using a z-distribution derived from the group mean and s.e

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Front Cell Neurosci (2021) 15:673217

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A different study found a significant reduction in pore size via a dermatoscopic analyzer after 60 women applied tretinoin 0.025% cream once daily for 90 days.[28] While the direct relationship between pore size and sebum production makes this interesting, one cannot conclude that topical retinoids decrease sebum production given that studies have not distinctly uncoupled this association

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