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Description
During stress, peripheral action and tissue sensitivity of those stress hormones depend largely on organ- and cell-specific GC signalling and the availability of GCs, which is regulated by corticosteroid binding globulins (CBGs) and 11 -HSD2 (11 -hydroxysteroid dehydrogenase type 2) [63, 64]

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The observed discrepancy may be due to the presence of a small amount of endogenous LAT1 in HEK293-LAT2 cells as discussed later

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There has been much speculation about the reasons for loss of ascorbate biosynthesis capacity but no easily testable hypotheses have emerged

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