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10.1016/j.neuron.2011.02.006 12 BreunigJ

Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice

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In summary, our data provided compelling evidence demonstrating that Tim-AIII promotes NSCLC ferroptosis by targeting and facilitating HSP90-mediated GPX4 ubiquitination and degradation, which in turn causes cell cycle arrest, inhibition of cell proliferation, and migration