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Furthermore it was found that 69% of the participants in the study reduced their initial body weight by at least 10%

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GLP-1 drugs slow digestion and suppress appetite, which can cause low energy from reduced nutrient intake or blood sugar fluctuations

Earlier SURMOUNT-1 data further reinforced these outcomes, with tirzepatide demonstrating weight loss of up to 22.5% of body weight over 72 weeks, the highest ever recorded for a pharmacological weight loss therapy at that time

(A) GLP-1 can induce fibronectin type III domain-containing protein 5 (FNDC5) expression in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT)

Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node