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However, more severe reactions, though rare, can occur and should be immediately addressed by medical professionals

Nat Rev Microbiol 2021;19(12):774-785

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This sets off oxidative stress, as mitochondrial dysfunction and enzyme activation generate large amounts of reactive oxygen and nitrogen species (ROS/RNS), damaging proteins, lipids, and DNA

Future research focuses on the development of selective NRF2 modulators, hepatocyte-targeted approaches such as proteolysis-targeted chimeras (PROTACs) and GalNAc-conjugated oligonucleotides, and biomarker-based patient stratification using genomic, immunohistochemical, and transcriptomic indicators of NRF2 activation

Bioinspired drug delivery strategies for repurposing conventional antibiotics against intracellular infections