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Description
The data on rhIGF-1 support the mechanistic rationale that an IGF-1 analog like LR3 (which has extended half-life and greater receptor availability in research settings) could enhance protein synthesis, stimulate cellular proliferation pathways and promote more efficient nutrient partitioning, though direct clinical trials of IGF-1 LR3 itself in humans are lacking
The study was observational and relatively small, but the findings were promising
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ERJ Open Res 2023;9:00633-2022
Type 2 Diabetes With Obesity CagriSema REDEFINE 2 showed 13.7% weight loss with 73.5% of T2D patients achieving HbA1c of 6.5% or less, exceeding semaglutide's glycemic and weight results in T2D trials
They trigger genetic expression changes that fundamentally alter how your skin cells behave, shifting the balance from breakdown toward regeneration
