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Description
An early study showed that intravenous or intracerebroventricular obestatin had no effects on pituitary hormone release (GH, prolactin, ACTH and TSH) in male rats (116), consistent with the fact that the obestatin receptor GPR39 is not expressed in the pituitary (115,117,118)

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Animal data provides biological plausibility and mechanistic insights but cannot guarantee human efficacy

Yan et al., 2024)

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Ethnic variations in UC genetic susceptibility Genetic susceptibility to UC varies among different ethnic groups, reflecting diverse genetic backgrounds and environmental interactions