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Limitation and Future Research Directions Despite the welldocumented neuroprotective effects of natural polyphenols, several critical limitations hinder their clinical translation in AD therapy

Iwabuchi T, Yoshimoto C, Shigetomi H, Kobayashi H

These findings suggest that the decline in endogenous melatonin levels with age may contribute to the onset or severity of age-related neurodegenerative disorders

However, the relationship between GST gene polymorphisms and viral diseases of the CNS remains unknown

Microbiology, 149 (3), 707714

Additionally, any patients who have absorption issues as a result of a bowel disease or surgery need to keep tabs on their levels