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2022) which requires the deactivation of tumour suppressor genes such as P53, RB and p16 (Dimri et al 2005) and/or activation of oncogenes

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Debt securities are subject to credit risk and interest rate risk, and high-yield securities and unrated securities of similar credit quality have a much greater risk of default and their values tend to be more volatile than higher-rated securities with similar maturities

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