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Within this framework, -syn aggregation has long been described by the classical nucleationpolymerization model [279]

As demonstrated in an experimental mouse model, the use of peptide-based senolytics has shown promise by reducing senescence RPE cells, improving visual function, but more importantly slowing the progression of geographic atrophy

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These two steps resemble the first two reactions in the Krebs cycle, catalyzed by citrate synthase and aconitase, respectively