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50 The identification of circulating biochemical biomarkers represents a promising avenue for noninvasive GBM detection and monitoring

This process releases a significant amount of intracellular mature alarm factors, such as IL-1 , IL-18, high mobility group protein B1, and various damage-associated molecular patterns (DAMPs) into the extracellular space

In the field of histone modification, panobinostat, an HDAC inhibitor that belongs to the cinnamic hydroxamic acid class of compounds that inhibits HDAC1, 36 at nanomolar concentrations [133, 134], has exhibited cytotoxic effects by inducing cell cycle arrest and apoptosis in ATC cell lines both in vitro and in vivo [51], but its clinical efficacy remains limited

In vivo ALA can be reduced to the dithiol form (where the ring structure is broken) called dihydrolipoic acid (DHLA)

doi: 10.1038/sj.cdd.4400998 82 RajuD.HusseyS.AngM.TerebiznikM

The X-chromosome inactivation (XCI)-related gene, XIST , is responsible for XCI
