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Important factors potentiating AKI in these patients are extracellular volume depletion due to vomiting, diarrhoea, urinary tract obstruction, fluid and electrolyte disturbances, exposure to contrast media, nephrotoxic antibiotics, non-steroidal anti-inflammatory drugs and nephrotoxicity of some of the anti-cancer treatments [24]

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In the setting of isolated methylene blue administration purple urine raises the concern for acute hemolytic anemia secondary to glucose-6-phosphate dehydrogenase deficiency [1]

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