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Therefore, the introduction of nanoparticles with GSH-responsive or -depleted characteristics can effectively sensitize radiotherapy and further significantly improve the anticancer therapeutic effect
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Preclinical and mechanistic studies indicate that AZD3965 is particularly effective in tumors characterized by high MCT1 and low MCT4 expression, especially in certain lymphoma subtypes, where inhibition of lactate transport induces intracellular acidification and metabolic stress
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