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In one form of resistance, a cancer drug causes biological effects that counteract how the drug works to kill cancer cellsthat is, its mechanism of action
High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate

10.1016/j.isci.2025.112609 221
Montane, J
Iwanaga S, Saito N, Sanae H, et al

Studies like those by Manukhina et al