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doi: 10.1016/j.jep.2023.116604 9 KongLZhaoQJiangXHuJJiangQShengLet al

** Based on a clinical study from week 1 to week 4 compared to baseline

These effects stem from the peptide itself, not the B12

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A different randomized, double-blind, placebo-controlled clinical trial demonstrated that daily oral administration of equal-lower doses (5 g/day) of l-ARG for a shorter period (6 weeks) compared to the current study induced a significant subjective improvement of penile erectile function, as assessed through standardized OLeary questionnaire for ED, although without a significant improvement of penile vascular parameters assessed by basal PDU, in 29 middle-aged/elderly men affected by organic ED of mixed etiology and unknown severity, therefore reporting, in line with the results of the current study, a discrepancy between subjective and objective improvement in erectile function [28]