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There were no significant food consumption differences at 23 C and interestingly, at thermoneutrality PDSS2 BKO had decreased food consumption compared to PDSS2 FL , suggesting that increases in metabolic rates were not due to increased food consumption in the knockout animals

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The toxicity of dopamine has been demonstrated in a variety of in vitro models, and previous experiments have demonstrated the selective toxicity of dopamine in vivo after exogenous dopamine injection into the striatum, resulting in the selective toxicity of dopamine receptor nerve terminals and the loss of dopaminergic neurons in the substantia nigra [202,203]