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2011 Apr;85(4):273-84

After 4 weeks of oral administration of 5amino1mq tablets (510 mg/kg) to aged mice (1820 months old), muscle mass was significantly increased, grip strength was enhanced by approximately 40% compared with the control group, and muscle endurance and exercise capacity were also notably improved.Further studies revealed that 5amino1mq inhibits excessive NNMT activation in muscle tissue, restores NAD levels, activates the SIRT1 pathway, reduces muscle protein degradation, and promotes muscle protein synthesis, thereby maintaining muscle mass

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The blots were then washed again 65 min and then exposed to ECL substrate (GE Healthcare, UK) for 1 min, and developed onto Kodak XPS films

doi: 10.1016/j.dsx.2017.03.017
10.1016/j.ejphar.2014.10.048
