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Individualized titration is essential to achieve serum trough levels in the mid-normal physiologic range, thereby minimizing adverse effects such as erythrocytosis, gynecomastia due to aromatization, or suppression of endogenous spermatogenesis

Low levels of B12 could potentially lead to a decrease in the production of serotonin ultimately causing or contributing to depression

Because both protocols use a before-bed injection on a 5-days-on/2-days-off schedule, they run cleanly in parallel with no scheduling conflict

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This is because they are needed to support fetal development