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Smoking also reduces saliva production that normally helps neutralize refluxed acid and clear it back to the stomach

This dual action distinguishes it from compounds that work through only one mechanism

doi: 10.1073/pnas.92.15.6728

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However, they come with their set of challenges, and needle-averse patients often yearn for an alternative

In this case, giving vitamin B 3 does not result in significant improvement, and this failure helps to establish the diagnosis of vitamin B 6 deficiency
