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A 2-fold increase in GST activity was found in lymphocytes from chronic lymphocytic leukemia (CLL) patients, who were resistant to chlorambucil, relative to lymphocytes from untreated CLL patients [7]

*Includes CYP2D6 phenoconversion and pharmacogentics while predicting phenotype and compared treatment outcome with usual care group

Eckersley-Maslin MA, Alda-Catalinas C, Reik W

(2020) 10.1056/NEJMoa2007764 133

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In terms of kinase enrichment, pathways related to cell cycle, DNA damage response, cell proliferation and regulation of cytoskeleton organization account for the effects of (M+D)/2 and (M+D+V)/3 compared to the addition of single agents (LIMK1, TESK1, P70S6K, CDK1, CDK2, CAMK4, CAMK2B) ( Figures 7C, D )