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RNA-seq data analysis result of a retinal I/R mouse model showed RGC ferroptosis contributes simultaneously to retinal damage after I/R, through Steap3 promoting the glutamate, and ferrous iron generation, which trigger ferroptosis in ischemic RGC (Dvoriantchikova et al., 2022)

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targeted therapy in RCC)by clarifying disease-specific regulatory mechanisms: PKD1 mutation-driven mitochondrial defects in ADPKD, DPP9-Nrf2-mediated sorafenib resistance in RCC, and PPARFABP1 axis dysregulation in IgA nephropathy, alongside shared core pathways (e.g., GPX4/SLC7A11 as central checkpoints)

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Glutathione deficiency is the leading cause of ageing

At least for the mouse GPx-1 gene, a 3 enhancer region with GATA nuclear factor binding sites regulates transcription in erythroid cells, which have a higher rate of expression compared to tissues such as brain (271)