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Because the target range is the condition at which optimization of desired efficacy converges with acceptable toxicity risk, the time in target range (TTR) should be maximized

doi: 10.1056/NEJMoa1908639 127 MingioneA.Dei CasM.BonezziF.CarettiA.PiccoliM.AnastasiaL.et al

PZ: Investigation, Supervision, Writing review & editing

The metabolism of peptides and proteins usually starts from the action of endopeptidase and then undergoes multi-step enzymatic degradation to produce the final metabolite amino acids, which enter the amino acid pool in vivo (Vugmeyster et al., 2012)

How peptides degrade over time The chemistry behind peptide shelf life

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