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In addition, several immunosuppressive cells, such as MDSCs, DCregs, and Bregs, can convert resting CD4 T cells into immunosuppressive Tregs [104, 105]

Neural communication depends on the release of neurotransmitters

This disruption counteracts the immunosuppressive TME in PDAC, enhancing therapeutic efficacy

Copper-based nanomaterials assembled from copper compounds have been widely used to induce necroptosis in tumor cells

Washington (DC): National Academies Press (US) (1998)

Moreover, selenium and other trace element supplements, though biologically active, carry a narrow therapeutic window, and overdosing could exacerbate organ dysfunction or induce toxicity (stnda, 2023)