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Meanwhile, the roles of GH and IGF1 are influenced by GH-binding proteins (GHBPs) and IGF-binding proteins (IGFBPs), respectively (Duan and Xu, 2005)

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25 A more effective method of diagnosis is to use serum B 12 measurements in conjunction with other biomarkers, namely, homocysteine (Hcy), methylmalonic acid (MMA), and holo-transcobalamin (holo-TC)