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Placebo-treated participants showed either no improvement or worsening of these measures over time

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doi: 10.1038/s41586-023-06546-y 63 MaEHDahabiehMSDeCampLMKaymakIKitchen-GoosenSMOswaldBMet al

ACA acetoacetate AD Alzheimer's Disease AGE advanced glycation end products BBB blood-brain barrier HB -hydroxybutyrate CAT carnitine acetyltransferase CR caloric restriction ETC electron transport chain FAO fatty acid -oxidation FOXO3A forkhead box O3A GLUT-1 Glucose transporter 1 GSH-Px glutathione peroxidase HCA2 Hydroxy-carboxylic acid receptor 2 HDACs histone deacetylases HO-1 heme oxygenase-1 KBs ketone bodies KD Ketogenic diet MCT monocarboxylate transporter mPT mitochondrial permeability transition PD Parkinson's Disease PPAR peroxisome proliferator-activated receptor PUFAs polyunsaturated fatty acids RNS reactive nitrogen species ROS reactive oxygen species SOD superoxide dismutase TBI traumatic brain injury TCA tricarboxylic acid UCP uncoupling protein

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