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Accessed April 24, 2025

My appetite under control

Compounded tirzepatide has soared in popularity as people have sought cheaper alternatives to the brand-name drugs

My general framework: Start with semaglutide if cost is a significant concern, or if there is no strong reason to expect poor tolerance Start with tirzepatide if the patient has tried semaglutide before and struggled with side effects, if faster initial response matters clinically, or if the patients goals require larger total weight loss Switch to tirzepatide if a patient on semaglutide is experiencing persistent nausea or has plateaued and escalation options are limited One pattern worth noting: men I see a consistent pattern with male patients who struggle to tolerate semaglutide nausea and GI disruption can be particularly disruptive for them, and theyre often less willing to push through it

Efficacy and Safety of GLP-2 (T) in Type 2 Diabetes
Because of the significant risks associated with compounded tirzepatide, the FDA strongly recommends using an FDA-approved tirzepatide drug like Zepbound or Mounjaro when it is available