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If the individual has significant accumulation (older age, chronic disease, prior chemotherapy), the first course may produce the most noticeable effects Subsequent courses: Target newly accumulated senescent cells

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[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Mitsche MA, Hobbs HH, Cohen JC

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N Engl J Med 348:21102124 Carta M, Murru L, Barabino E, Talani G, Sanna E, Biggio G (2008) Isoniazid-induced reduction in GABAergic neurotransmission alters the function of the cerebellar cortical circuit

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