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Uric acid is reduced in the substantia nigra in Parkinsons disease: effect on dopamine oxidation
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Once activated, microglia release pro-inflammatory cytokines such as TNF- and IL-6, which intensify brain inflammation and cause further neuronal damage
doi: 10.1182/blood-2008-05-159301
Xanthine dehydrogenase (XDH) requires Moco, FAD, and two iron-sulfur clusters (Hille et al., 2011), and its main function is associated to purine degradation by oxidizing hypoxanthine to xanthine and xanthine to uric acid in the cytosol
