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doi: 10.1371/journal.pone.0161158 [DOI] [PMC free article] [PubMed] [Google Scholar] 38

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Insulin normally suppresses gluconeogenesis while promoting lipogenesis, however, under insulin resistant states such as T2D, hepatic lipogenesis remains insulin sensitive and suppression of gluconeogenesis is insulin resistant, leading to a metabolic state called selective hepatic insulin resistance (199)