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Another critical area that requires attention is the potential of ferroptosis in overcoming gemcitabine resistance, which is a major challenge in PDAC treatment

Although choroidal melanin seems to be synthesized throughout life, melanin in the RPE is synthesized for a brief interval of fetal and perinatal life with little production thereafter [5658]
[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Carter A.B., Tephly L.A., Venkataraman S., Oberley L.W., Zhang Y., Buettner G.R., Spitz D.R., Hunninghake G.W

Notably, astrocytes exhibit high Nrf2 activity, whereas neurons rely on astrocytic Nrf2-mediated protection

Originally developed as an anesthetic, ketamine has been repurposed in recent years as a treatment option for certain mental health conditions

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