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Slow or no absorption of FODMAPs results in an increase in osmotic action, resulting in increased luminal water content and subsequent distention of the small intestine, leading to IBS symptom induction [76]

ChangCHChenYSYanagidaF (2011)

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When glutathione runs out, the toxic metabolite (NAPQI) destroys liver cells.[3] Even regular, safe doses chip away at your reserves

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Functional studies in neurons and cell lines under physiologic conditions, again utilizing voltage-gated calcium channel modulation by MOR, have also failed to detect constitutive MOR activity after chronic exposure to morphine in locus coeruleus (Connor et al., 1999) and periaqueductal gray neurons (Bagley et al., 2005b) or ShSY5Y cells (Kennedy and Henderson, 1992)