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Indeed, GCLC has non-canonical functions in sequestering glutamate levels to prevent ferroptosis 51

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Common Deficiency Warning Signs: B12 deficiency often develops gradually, making symptoms easy to dismiss initially

However, their contribution is context-dependent, as genetic ablation of ABCC1 does not fully prevent apoptosis-associated GSH loss in certain models 43 , indicating the existence of compensatory or alternative efflux mechanisms