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This accelerates the appearance of fine lines and a general loss of plumpness and resilience in the skin
Insulin receptor substrates mediate distinct biological responses to insulin-like growth factor receptor activation in breast cancer cells

3 ArcielloM.RotilioG.RossiL

It is a key substrate for the synthesis of proteins and nucleotides, supporting cell growth and division

doi: 10.1084/jem.20110367
