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Our findings, using genetic models and isotope tracing, are consistent with a model in which CrAT produces acetylcarnitine from acetyl-CoA in mitochondria and then following export to the cytosol, it converts acetylcarnitine back to acetyl-CoA as an alternative to ACLY for two carbon transfer from mitochondria (Figure 7A)

However, the findings are mixed and more detailed research is needed

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The study design was 2 months of wash-out, 6 months of therapy, and 2 months of follow-up

doi: 10.1016/j.bpsgos.2021.06.010

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