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Thus, creatine has evolved from a phosphate shuttle to a systemic metabolic orchestrator , integrating energy sensing (AMPK/mTOR), allocation (mitochondrial networking), and dissipation (futile cycling)

The peptides stimulatory effect on muscle growth and tissue repair attracted the attention of athletes and trainers to whom increased strength and shorter recovery times are advantageous

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Such individualized approaches will enhance therapeutic efficacy and reduce the risk of adverse effects from systemic treatments

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