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Description
For now, the existing thyroid treatment paradigm leaves a lot to be desired, which means extra help outside of traditional medications and treatments is often needed

In this work, by noting that pre-equilibration of ligand-receptor and ternary complex formation occur faster than the receptor internalization and downregulation, we formulate a minimal kinetic model to offer a semi-quantitative yet predictive understanding of the GPCR desensitization and down-regulation

References Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, et al

J Clin Oncol 2013;31:1271-6

Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked mutant TDP-43 proteins

Nunes JC, Torres AG
