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This reaction with the peptides would form cross-links without the restrictive specificity for endogenous glutamine

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Notably, ATPcitrate lyase has been shown in pulmonary vascular diseases, including PAH, to regulate the glycolysislipogenesis metabolic axis and GCN5-mediated epigenetic mechanisms, promoting proliferation and migration of vascular smooth muscle cells

10.1002/mds.23838 Mov

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These four mechanisms act in concert across musculoskeletal, gastrointestinal, and CNS tissue in preclinical models