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Elucidation of the molecular mechanisms underlying sorafenib-induced hepatotoxicity

doi: 10.1111/aji.13593 163 FadinMNicolettiMCPellizzatoMAccardiMBaiettiMGFratterA

This treatment restored NAD + levels, improving mitochondrial function 164

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It supports metabolic processes that promote a clear complexion and may reduce dryness

This results in the activation of the transcription factors Smad2, Smad3, and Akt, which regulate target gene expression (type I procollagen), thereby increasing the induction of the expression of COL1A1 mRNA expression via the TGF- signaling pathway (Fig