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A central aspect of its activity observed in research models is its profound influence on angiogenesis, the formation of new blood vessels

In this context, hormones such as melatonin and cortisol, as well as circulating elements in blood or lymphatic fluid, including immune cells, neuropeptides, and neurotransmitters like dopamine, noradrenaline, and serotonin, are key components of the circadian system (Linsell et al., 1985

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RNA-seq and transcriptomic analysis revealed that Auranofin and the combination with COJEC significantly downregulated pathways associated with tumor malignancy and metastatic capacity, such as MTORC1 signaling, glycolysis, Notch signaling, KRAS signaling, WNT- catenin signaling, hypoxia, angiogenesis, IL-6/JAK/STAT3 signaling, and epithelial-to-mesenchymal transition (Fig