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Elevated levels of ROS and oxidative stress in chondrocytes play a role in the development of KOA (Blanco et al., 2011)

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Emadis group also uncovered that reducing glutamine resulted in a decrease of the metabolite 2-hydroxybutyric acid (2-HG) and thus inhibited the proliferation of AML cells with isocitrate dehydrogenase (IDH) mutations [18]

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